The membrane strikes back: phosphoinositide binding regulates Skywalker function

Steven J Del Signore; Avital A Rodal

doi:10.1038/nsmb.3313

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The membrane strikes back: phosphoinositide binding regulates Skywalker function

Steven J Del Signore and Avital A Rodal

Nature structural & molecular biology, Vol.23(11), pp.956-957

11/04/2016

DOI: https://doi.org/10.1038/nsmb.3313

PMID: 27814349

Abstract

Biophysical Phenomena

Cell Membrane

Humans

Phosphatidylinositols

Protein Binding

Cell Biology

Cell Components

Genetic Disorders

Mutation

Drosophila Skywalker regulates the GTPase Rab35, thereby controlling the turnover of synaptic-vesicle proteins. A new crystal structure of the TBC domain of Skywalker reveals an unexpected phosphoinositide-binding pocket, which is critical for synaptic function and is disrupted in DOORS syndrome–causing mutations in the human Skywalker homolog TBC1D24.

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Title: The membrane strikes back: phosphoinositide binding regulates Skywalker function
Creators: Steven J Del Signore - Department of Biology, Brandeis University, Waltham, Massachusetts, USA
Avital A Rodal - Department of Biology, Brandeis University, Waltham, Massachusetts, USA
Publication Details: Nature structural & molecular biology, Vol.23(11), pp.956-957
Grant note: T32 NS007292 / NINDS NIH HHS
Identifiers: 9924014243501921
Academic Unit: Rosenstiel Basic Medical Sciences Research Center; Department of Biology; Benjamin and Mae Volen National Center for Complex Systems; Interdepartmental Program in Neuroscience
Language: English
Resource Type: Journal article

The membrane strikes back: phosphoinositide binding regulates Skywalker function

Abstract

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