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The precipitation of precursor tRNA in high salt
Journal article   Peer reviewed

The precipitation of precursor tRNA in high salt

M Rosbash and S Penman
Biochemical and biophysical research communications, Vol.46(3), pp.1469-1475
1972
DOI: https://doi.org/10.1016/S0006-291X(72)80142-6
PMID: 5012181

Abstract

The tRNA precursor molecules from HeLa cells are 50% precipitable in two molar NaCl, while the mature tRNAs are almost completely (greater than 95%) soluble. This provides a simple and rapid method for the preparation of pre-tRNA molecules relatively free of their mature tRNA products.

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