The Rho-family GTPases act downstream of axon guidance receptors, controlling proteins that remodel the cytoskeleton. New work now suggests that these GTPases also team up to regulate activation of the semaphorin-3A receptor itself.
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Title
Tinker to Evers to Chance: semaphorin signaling takes teamwork
Creators
Paul A Garrity -
Department of Biology, Massachusetts Institute of Technology