Abstract
Diazepam is a commonly used anxiolytic drug and has been used in obstetric practice during labor. Ex vivo experimental studies have shown that diazepam can cause decreased uterine muscle contraction strength and rate, suggesting that diazepam could prolong labor. Prolonged labor, particularly in the second stage, increases the risk of adverse maternal and fetal outcomes. We conducted a systematic review and meta-analysis, following PRISMA Guidelines, of clinical studies that evaluated whether diazepam is associated with increased labor duration.