Incidence Trends and Burden of Human Papillomavirus-Associated Cancers Among Women in the United States, 2001-2017

Ashish A Deshmukh; Ryan Suk; Meredith S Shiels; Haluk Damgacioglu; Yueh-Yun Lin; Elizabeth A Stier; Alan G Nyitray; Elizabeth Y Chiao; Gizem S Nemutlu; Jagpreet Chhatwal; Kathleen Schmeler; Keith Sigel; Kalyani Sonawane

doi:10.1093/jnci/djaa128

Journal article

Incidence Trends and Burden of Human Papillomavirus-Associated Cancers Among Women in the United States, 2001-2017

Ashish A Deshmukh, Ryan Suk, Meredith S Shiels, Haluk Damgacioglu, Yueh-Yun Lin, Elizabeth A Stier, Alan G Nyitray, Elizabeth Y Chiao, Gizem S Nemutlu, Jagpreet Chhatwal, …

Journal of the National Cancer Institute : JNCI, Vol.113(6), pp.792-796

06/01/2021

DOI: https://doi.org/10.1093/jnci/djaa128

PMCID: PMC8168114

PMID: 32833021

Abstract

Alphapapillomavirus

Incidence

Papillomaviridae

Papillomavirus Infections - complications

Papillomavirus Infections - epidemiology

Papillomavirus Infections - prevention & control

United States - epidemiology

Uterine Cervical Neoplasms

Research Support, N.I.H., Extramural

Research Support, N.I.H., Intramural

Cancer or Carcinogenesis

Abstract Human papillomavirus (HPV)-associated anal and oropharyngeal cancer incidence has increased in recent years among US women. However, trends in incidence and burden (annual number of cases) of noncervical HPV-associated cancers relative to cervical cancer remain unclear. Using the 2001-2017 US cancer statistics dataset, we evaluated contemporary incidence trends and burden (annual number of cases) of HPV-associated cancers among women by anatomic site, race or ethnicity, and age. Overall, cervical cancer incidence plateaued among White women but continued to decline among Black and Hispanic women. Anal cancer incidence surpassed cervical cancer incidence among White women aged 65-74 years of age (8.6 and 8.2 per 100 000 in 2015) and 75 years or older (6.2 and 6.0 per 100 000 in 2014). The noncervical cancer burden (n = 11 871) surpassed the cervical cancer burden (n = 11 527) in 2013. Development of efficacious screening strategies for noncervical cancers and continued improvement in cervical cancer prevention are needed to combat HPV-associated cancers among women.

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Title: Incidence Trends and Burden of Human Papillomavirus-Associated Cancers Among Women in the United States, 2001-2017
Creators: Ashish A Deshmukh - Center for Health Services Research, Department of Management, Policy and Community Health, UTHealth School of Public Health, Houston, TX, USA
Ryan Suk - Center for Health Services Research, Department of Management, Policy and Community Health, UTHealth School of Public Health, Houston, TX, USA
Meredith S Shiels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Haluk Damgacioglu - Center for Health Services Research, Department of Management, Policy and Community Health, UTHealth School of Public Health, Houston, TX, USA
Yueh-Yun Lin - Center for Health Services Research, Department of Management, Policy and Community Health, UTHealth School of Public Health, Houston, TX, USA
Elizabeth A Stier - Department of Obstetrics and Gynecology, Boston Medical Center/Boston University School of Medicine, Boston, MA, USA
Alan G Nyitray - Clinical Cancer Center/Center for AIDS Intervention Research, Medical College of Wisconsin, Milwaukee, WI, USA
Elizabeth Y Chiao - Department of General Oncology, MD Anderson Cancer Center, Houston, TX, USA
Gizem S Nemutlu - Massachusetts General Hospital Institute for Technology Assessment, Harvard Medical School, Boston, MA, USA
Jagpreet Chhatwal - Massachusetts General Hospital Institute for Technology Assessment, Harvard Medical School, Boston, MA, USA
Kathleen Schmeler - Department of Gynecological Oncology, MD Anderson Cancer Center, Houston, TX, USA
Keith Sigel - Department of General Internal Medicine, Mt. Sinai Icahn School of Medicine, New York, NY, USA, Department of Medicine, Mt. Sinai Icahn School of Medicine, New York, NY, USA
Kalyani Sonawane - Center for Health Services Research, Department of Management, Policy and Community Health, UTHealth School of Public Health, Houston, TX, USA, Center for Healthcare Data, Department of Management, Policy and Community Health, UTHealth School of Public Health, Houston, TX, USA
Publication Details: Journal of the National Cancer Institute : JNCI, Vol.113(6), pp.792-796
Publisher: Oxford University Press (OUP)
Grants: R01 CA232888, National Cancer Institute (United States, Bethesda) - NCI
Grant note: R01 CA232888/CA/NCI NIH HHS/United States
Identifiers: 9924037161501921
Academic Unit: Brandeis International Business School
Language: English
Resource Type: Journal article

Incidence Trends and Burden of Human Papillomavirus-Associated Cancers Among Women in the United States, 2001-2017

Abstract

UN Sustainable Development Goals (SDGs)

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